Frio®Pen • Crypointer

Treatment with the Frio Pen Barbor Spot Reducer is a highly effective, non-invasive method for the targeted removal of epidermal pigmentation disorders such as lentigines (age spots), solar hyperpigmentation, or minor epidermal lesions. Based on cryotherapy technology, the Frio Pen offers precise, temperature-controlled application of cold – down to -89°C – directly to the affected skin areas.

In contrast to thermal procedures such as laser treatment, which aim for selective photothermolysis through photothermal stimuli, the Frio Pen uses extreme cold for controlled, cellular denaturation of pigmented tissue. The rapid cooling leads to intracellular ice crystal formation, which selectively destroys melanin-containing cells without thermally stressing surrounding healthy tissue.

Advantages over laser treatment

• Lower side effect profile: No thermal damage to adjacent tissue structures, minimized risk of post-inflammatory hyperpigmentation
• Low pain: Local cooling achieves natural analgesia, making the treatment almost painless
• Minimal downtime: No open wound is created – the treated lesions heal secondary-intentionally with scab formation, which enables rapid re-epithelialization
• Safe for photosensitive skin: Can also be used on higher Fitzpatrick skin types, as no light-based energy is used.

The Frio Pen's microtip technology allows for precise, targeted application of cold with high control over penetration depth and exposure time. The affected pigment cells are specifically frozen while the surrounding tissue remains intact – a method that combines the highest dermatological precision with cosmetically excellent results.

This treatment is the ideal solution for patients seeking an effective, low-risk alternative to invasive pigment correction procedures. The dermatologically validated technology of the Frio Pen Barbor Spot Reducer sets new standards in aesthetic cryotherapy.